Myasthenia Gravis, is weakness and fatigue in any muscle that you have voluntary control of. It is caused by a disruption in the normal communication between muscles and nerves.
Myasthenia Gravis is a condition that cannot be treated. Although this disease can affect anyone, it is more prevalent in those under 40 years of age and older.
Signs of Myasthenia Gravis
Myasthenia gravis causes muscle weakness that worsens with each use of the affected muscle. Muscle weakness can occur at any time, and symptoms tend to improve when you rest. The symptoms can get worse over time and usually become more severe within a few years.
Myasthenia gravis can affect any muscle you control voluntarily. However, some muscles are more frequently affected than others.
- Eye muscles
More than half of those who have myasthenia Gravis experience eye problems as their first symptoms.
Ptosis is the drooping of one or both of your eyelids.
Double vision (diplopia) can be horizontal or vertical and is improved or resolved when one eye closes.
- Throat and Face Muscles
About 15% of myasthenia gravis sufferers experience symptoms that start with the throat muscles and face.
Impair speaking. Depending on the condition of your muscles, your speech may sound nasal or soft.
It can cause difficulty swallowing. Choking can make it difficult to swallow, drink, or eat. Sometimes liquids that you are trying to swallow may escape your nose.
Eating disorders can affect chewing. If you eat a hard food like steak, your muscles may become tired halfway through the meal.
You can change facial expressions. Your smile could look like a snarl, for example.
- Muscles of the neck and limbs
Myasthenia gravis can cause weakness in your neck and arms, as well as your legs. How you walk can be affected by weakness in your legs. It can be difficult to raise your head if you have weak neck muscles.
When should you see a doctor?
If you are having following difficulties, talk to your cardiothoracic surgeon Singapore:
- Use your hands or arms
- Keep your head up
Causes of Myasthenia Gravis
Your nerves communicate with your muscles through the release of chemicals (neurotransmitters). These chemicals fit perfectly into the receptor sites of the muscle cells at nerve-muscle junction. Your muscles will experience weakness if there are fewer nerve signals available to them.
Antibodies can also be used to block the function a protein called muscle specific receptor tyrosine-kinase (TIE’roh-seen KI-nays), sometimes known as MuSK. This protein is responsible for the formation of the nerve-muscle junction. Antibodies against this protein can cause Myasthenia gravis. Research studies have also reported other antibodies. The number of these antibodies will likely increase over time. Myasthenia gravis can be caused by antibodies that block acetylcholine or MuSK, but not LRP. This is also known as antibody-negative myasthenia graveis or seronegative myasthenia Gravis. Researchers assume that these types still have an autoimmune basis, but it is not yet possible to detect the antibodies.
Your immune system’s thymus gland can be found in your upper chest, just below your breastbone. The thymus gland is believed to trigger or maintain the production of antibodies that block Acetylcholine, according to researchers.
Thymus gland grows large in infancy but is smaller in adulthood. The thymus gland can be abnormally large in some people with this disease. Such patients may also develop tumors of their thymus gland (thymomas). Thymomas don’t usually turn out to be cancerous, but they could become cancerous.
Rarely, myasthenia Gravis mothers have children with myasthenia Gravis (neonatalmyastheniagraveis).
Factors that could worsen it:-
- Infection or illness
- Some medications, such as quinidine, quinidine, quinidine, quinidine, quinidine Sulfate, quinine, Quialaquin, phenytoin and certain anesthetics, may be regulated.
- Periods for menstruation
Although complications of myasthenia Gravis can be treated, some may prove to be life-threatening.
Myasthenic crises is a serious condition in which the muscles controlling breathing stop working properly. It requires medical assistance and emergency treatment. People can breathe again using medications and blood-filtering treatments.
- Tumors of the thymus gland
It is a condition in which a tumor develops in the thymus, a gland located under the breastbone and that controls the immune system. These tumors, also called thymomas or thymomas are not cancerous.
- Other disorders
Myasthenia gravis Singapore patients are more likely to experience the following conditions:
Overactive or underactive thyroid. The thyroid gland is located in the neck and secretes hormones to regulate your metabolism. You might experience problems with weight gain, cold and other conditions if your thyroid gland is not functioning properly. A hyperactive thyroid can lead to problems with heat, weight loss, and other issues.
Autoimmune conditions: Myasthenia gravis patients might have more autoimmune conditions such as lupus or rheumatoid.